Membrane Proteins under mechanical stress

1.    Wijerathne TD*, Ozkan AD & Lacroix JJ*. (2023) Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch. Journal of General Physiology, PMID: 36715688

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2.    Jiang W, Lacroix JJ, Luo LL*. (2022) Importance of Molecular Dynamics Equilibrium Protocol on Protein-lipid Interactions near Channel Pore. Biophysical Reports, PMID: 36425669

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3.    Wijerathne WD, Ozkan AD, Lacroix JJ*. (2022) Yoda1's energetic footprint on Piezo1 channels and its modulation by voltage and temperature. Proceedings of the National Academy of Sciences U S A, PMID: 35858335

4.    Yoo S, Mittelstein DR, Hurt RC, Lacroix JJ, Shapiro MG*. (2022) Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Nature Communications, PMID: 35078979

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5.    Ozkan AD, Gettas T, Sogata A, Phaychanpheng W, Zhou M, Lacroix JJ*. (2021) Mechanical and chemical activation of GPR68 (OGR1) probed with a genetically-encoded fluorescent reporter. Journal of Cell Science, PMID: 34322699 
Selected as "Research Highlights" by Journal Editors

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6.    Lacroix JJ*. (2021) Dichotomy between heterotypic and homotypic interactions by a common chemical law. Physical Chemistry Chemical Physics, PMID: 34241615
Selected as "2021 HOT PCCP articles"

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7.    Jiang W, Del Rosario JS, Botello-Smith W, Zhaoc S, Lin YC, Zhang H, Lacroix JJ*, Rohacs T*, Luo YL*. (2021) Crowding-induced Opening of the Mechanosensitive Piezo1 Channel in Silico. Communications Biology, PMID: 33469156
Selected for a special issue on Mechanobiology

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8.    Xie C, Jiang W, Lacroix JJ, Luo Y*, and Hao J*. (2020) Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling. International Journal of Molecular Sciences, PMID: 32899497

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9.    Botello-Smith W, Zhang H, Ozkan AD, Jiang W, Pham CN, Lacroix JJ* and Luo Y*. (2019) A molecular Mechanism for the Chemical Activation of the Mechanosensitive Piezo1 Channel, Nature Communications, PMID: 31582801

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10.    Lacroix JJ*, Ozkan A (2019). Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy. Journal of Visualized Experiments, PMID: 30663695

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11.    Lacroix JJ*, Botello-Smith WM, Luo Y. (2018) Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nature Communications, PMID: 29795280

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12.    Brugarolas P, Sánchez-Rodríguez JE, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B* (2018) Development of a PET radioligand for potassium channels to image CNS demyelination. Scientific Reports, PMID: 29330383

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13.    Chatterjee P, Botello-Smith WM, Zhang H, Qian L, Alsamarah A, Kent D., Lacroix JJ, Baudry M*, Luo Y*. (2017) Can Relative Binding Free Energy Predict Selectivity of Reversible Covalent Inhibitors? Journal of the American Chemical Society, PMID: 29124934

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14.    Botello-Smith WM, Alsamarah A, Chatterjee P, Xie C, Lacroix JJ, Hao J*, Luo Y*. (2017) Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock. PLoS Computational Biology, PMID: 28827795

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15.    Labro AJ, Priest MF, Lacroix JJ, Snyders DJ*, Bezanilla F*. (2015) Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nature Communications, PMID: 26673941 

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16.    Kubota T, Lacroix JJ, Bezanilla F, Correa AM*. (2014) Probing α-310 Transitions in a Voltage-Sensing S4 Helix. Biophysical Journal, PMID: 25185547 
Highlighted by Giraldez, T. (2014) Let’s Twist (the S4) Again. Biophysical Journal 107, 1035-1037

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17.    Lacroix JJ, Hyde HC, Campos FV and Bezanilla F*. (2013) Moving Gating Charges through the Gating Pore in a Kv Channel Voltage Sensor. Proceedings of the National Academy of Sciences U S A, PMID: 24782544

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18.    Priest MF, Lacroix JJ, Villalba-Galea CA and Bezanilla F*. (2013) S3-S4 Linker length Modulates the Relaxed State of a Voltage-Gated Potassium Channel. Biophysical Journal, PMID: 24268143

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19.    Lacroix JJ, Campos FV, Frezza L, and Bezanilla F*. (2013) Molecular Bases for the Asynchronous Activation of Sodium and Potassium Channels Required for Nerve Impulses Generation. Neuron, PMID: 23972594
Highlighted by Braun, A.P. (2013) Built for speed: Molecular properties of the voltage sensor domain underlie the rapid activation of voltage-gated Na+ channels compared with Shaker-type K+ channels. Channels 7, 423-425

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20.    Labro AJ°, Lacroix JJ°, Villalba-Galea CA, Snyders DJ, and Bezanilla F*. (2012) Molecular Mechanism for Depolarization-induced Modulation of Kv Channel Closure. The Journal of General Physiology, PMID: 23071266
Highlighted by French, R.F. and Finol-Urdaneta, R.K. (2012) Open-state stabilization in Kv channels: Voltage-sensor relaxation and pore propping by a bound ion

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21.    Lacroix JJ and Bezanilla F*. (2012). Tuning the voltage sensor motion with a single residue. Biophysical Journal, PMID: 22947880

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22.    Allen MJ°, Lacroix JJ°, Ramachandran S, Capone R, Whitlock JL, Ghadge GD, Arnsdorf MF, Roos RP*, and Lal R*. (2012). Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiology of Diseases, PMID: 21930207

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23.    Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B and Bezanilla F*. (2012) Intermediate State Trapping of a Voltage-Sensor. The Journal of General Physiology, PMID: 23183699

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24.    Lacroix JJ, and Bezanilla F*. (2011). Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor. Proceedings of the National Academy of Sciences U S A, PMID: 21464282

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25.    Lacroix JJ, Labro AJ, and Bezanilla F*. (2011). Properties of deactivation gating currents in shaker channels. Biophysical Journal, PMID: 21354387
Highlighted by Shirokov, R. (2011) What's in gating currents? Going beyond the voltage sensor movement. Biophysical Journal 101, 512-514; discussion 515-516

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26.    Lacroix J, Halaszovich, CR, Schreiber DN, Leitner MG, Bezanilla F, Oliver D*, and Villalba-Galea*, CA (2011). Controlling the activity of PTEN by membrane potential. Journal of Biological Chemistry, PMID: 21454672

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27.    Pang V, Counillon L, Lagadic-Gossmann, D, Poet M, Lacroix J, Sergent O, Khan R, and Rauch C*. (2012). On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry. Cell Biochemistry and Biophysics, PMID: 22331497

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28.    Tekpli X, Huc L, Lacroix J, Rissel M, Poet M, Noel J, Dimanche-Boitrel MT, Counillon L, and Lagadic-Gossmann D*. (2008). Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains. Journal of Cell Physiology, PMID: 18264982

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29.    Lacroix J, Poet M, Huc L, Morello V, Djerbi N, Ragno M, Rissel M, Tekpli X, Gounon P, Lagadic-Gossmann D, and Counillon L*. (2008). Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks. Biochemistry, PMID: 19035652

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30.    Lacroix J, Poet M, Maehrel C, and Counillon L*. (2004) A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens. EMBO reports, PMID: 14710192